Thursday, August 21, 2008

Mid-tenure crisis

I have a confession to make. About a year ago I had managed to put myself in a position that should be avoided at all costs. In regards to my research program, I had become...


This is a bad, bad thing that no PI should ever do. I had been cruising along for about 7-8 years working away on a system, publishing a decent number of decent papers that garnered decent citations. Then about a year ago I was sitting on a bus going from Forsaken Conference Site in New England to the Boston airport. Sitting next to me was my good friend Rising Star Theoretician. RST turned to me and said, in more or less these words, "Your research program is going nowhere and you're in danger of becoming irrelevant." This was neither easy to hear, nor easy for RST to say. But he was right. Deep down I had known this for at least two years, but things were trundling along okay, so there was no immediate incentive to do anything about it. RST reminded me that there is always incentive to tend to the future of your research program. Having a future research program is the incentive.* I will always be in debt to RST for giving me a verbal kick in the pants.

I got lucky twice here. The first time was with RST's pep talk. The second time was a few months after that. I had just read a paper written by Benevolent Bioscientist, someone who had co-founded the field I was hoping to develop my new research program in. For reasons that are still unclear to me, BB had befriended me about a year previously and so I now knew him quite well. Anyway, the predictions he had made in this paper struck a chord. THIS was where I was headed. Or at least, some part of it. So I called BB to chat about his paper and the many opportunities it offered. BB told me I should work on protein X (one of the opportunities outlined in his paper). He said "I've been meaning to work on X for 10-15 years now and, to be honest, I don't think I'm ever going to get around to it. You should do it. Let me know how I can help." I knew protein X was important and I knew this was a generous offer. What I didn't quite grasp at the time was how important protein X is, and consequently how generous a gift this was. Protein X is a key player in not just one, not just two, but numerous disease states, including mental, cardiac and immune system disorders. And it's not understood at the molecular level. Protein X is an untapped goldmine that will lead to publications that are much more than "decent." And will lead me to NIH funding (I'm NSF-funded because of the nature of my previous work).

So here we are about a year after RST's pep talk. The old research program is (in hindsight predictably) rapidly dying. I have about one more decent publication I can squeeze out of that work. The all new research program based on protein X is still in its infancy, but it's growing stronger each day. Working on protein X has meant learning a whole new set of skills (I didn't train as a protein chemist), but fortunately I'm surrounded by colleagues who are willing to help. The timing is unfortunate (purely my own fault). I had to submit a renewal of my NSF grant in mid July. Obviously it had to be on protein X (there's plenty of basic science regarding X). It's not clear I had quite enough preliminary data (protein X is difficult to make because of its interesting properties), so I may be facing a funding gap for the first time.** But I'm having a blast in the lab. In fact, I'm more enthusiastic about my research than I have been in years. Staring from scratch again has been, and continues to be, hard. But I'm having fun.

* Have a written five year plan. It sounds dorky, but it works, and it should cover all aspects of your academic career. Read it and update it often. Never let your plan fall below the five year mark. If you can't see where your research might be five years from now, start developing a new research project with long term potential. Now.

** I'm working hard to avoid this. I will put in the two page update in the Fall, although I'm well aware those don't buy you much. More importantly I'll be presenting our data on protein X at a small meeting in early October. A number of the review panel members will be there, as will at least two of the people I suggested as reviewers (NSF does use reviewer suggestions - you'd be a fool not to provide some). With the exception of a much-needed two week vacation, since July I've been busting my guts making protein X and doing experiments. Come the end of September I will have the data. I hope.


Goose said...

Good luck and all the best with Protein X. It sounds like you have a good plan, and I truly believe good plans are usually rewarded.

While I've fled the protein chemistry field, I still remember the odd thing and if there's anything I can do to help please let me know.

JollyRgr said...

Good luck from me also.....and more importantly....I have a good feeling about this change of's right!

Abel Pharmboy said...

Came by via the good folks at DrugMonkey - they are much better at finding "new" old blogs than I.

You are very fortunate that RST felt comfortable to give you this kick in the pants but also that you were receptive (and not self-deceiving) enough to act upon it. Without knowing anything about your field, my guess would be that you'd continue pumping out the decent papers you describe but that you'd ultimately have trouble getting your grant renewed.

I had a senior committee member who changed fields (or a significant fraction of the their lab efforts) every ten years. It seemed to keep them quite energized.

I admire you for taking this step - might even be time for a little self-examination myself.

Candid Engineer said...

Visiting/staying via DrugMonkey.

Kudos to you for being receptive to constructive criticism. It is hard to hear, but invaluable. Really nice that your friend had the balls to be candid with you. Glad things are moving in an interesting new direction.

Milo said...

i'm jealous. i've been working on the same damn problem for 10 years and i don't get the choice to change.

i probably would have punched RST first, and then thanked him ;o)

Anonymous said...

I have always thought of things like 5yr plans were very general in nature, that is, the goals were general (to land a TT position, etc). But, as we all know, details matter.

I was just curious about your 5 year detailed is it? For example, do you plan out the number of pubs per year? Do you plan out which/how many grant deadlines to target? (All Without knowing how the data will turn out!)

Or are you more general about it

Anonymous said...

sorry, i will try to proofread my posts in the future and avoid using the word "general"

Odyssey said...

Good questions. I'm planning a post on five years plans. It might take a day or two or three. If I don't get around to it before the end of the week I'll post a quick reply as a comment here.

Samia said...

Woo! Good luck! :)